The Application of CFD to the Multi-Scale Characterization of Anti-Solvent Addition Crystallizations
نویسنده
چکیده
Anti-solvent crystallization can be used as an alternative to cooling or evaporation for the separation and purification of solid product in the pharmaceutical industry. Addition of antisolvent reduces the solubility of a solute in solution thereby facilitating the generation of supersaturation, the driving force for nucleation and growth. Some of the problems associated with anti-solvent crystallization are that it is poorly understood, can produce fine irregularly shaped crystals and is prone to the formation of polymorphs, solvates and hydrates.
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تاریخ انتشار 2006